Chelsea go into Sunday's game holding a 10-point lead over second-placed Arsenal and manager Jose Mourinho may have to thrust one of his young strikers into the fray.
Liverpool took over at the top of the Premier League table despite being held to a 0-0 draw against Manchester United in a scrappy match on Sunday.
IMAGES from the UEFA Champions League matches played on Wednesday.
Manchester City moved back into third place and almost guaranteed Champions League qualification thanks to a 3-1 home victory against West Bromwich Albion on Tuesday at the Etihad Stadium.
Arsenal knock out Cup holders Liverpool There were no such problems for Chelsea, however, as a Frank Lampard hat-trick helped them thump Macclesfield in the FA Cup.
A stoppage time goal by a heavily-bandaged Martin Skrtel spared Liverpool another deflating defeat as they drew 2-2 at home to Arsenal in the Premier League.
Kurt Zouma and Eden Hazard scored the goals the goals in a match that saw Diego Costa play central character.
Arsenal slumped to a last-gasp 2-1 Premier League defeat at relegation-threatened Brighton & Hove Albion on Saturday in a blow to the London club's chances of securing European football next season. Watford's Craig Dawson grabbed a stoppage-time equaliser with an overhead kick to earn his side a 1-1 draw with Leicester City on Saturday and a vital point in their battle for Premier League survival.
Former England captain Nasser Hussain hailed "magical" Jasprit Bumrah for his remarkable spell against England and felt that India pacer ended up being the difference between both sides in Vizag Test.
Robert Lewandowski scored a brilliant free kick to give Bayern Munich a 1-0 win over Atletico Madrid in their last Champions League Group D outing on Tuesday, ending the 100 percent record of their opponents. The Poland international curled the ball over the wall and into the corner of the net in the 28th minute but the goal had no impact on the final standings with Atletico guaranteed top spot and Bayern in second place.
Arsenal coach Arsene Wenger will be without right back Mathieu Debuchy for a "longer period" of time and is struggling with defensive options for their Champions League group opener against Dortmund.
Chelsea's Ruben Loftus-Cheek had a Europa League night to remember by scoring the first hat-trick of his career as the midfielder inspired them to a 3-1 home win over Belarus champions BATE Borisov on Thursday.
Juventus scored twice in a minute as they came from behind to clinch a dramatic 3-2 win over Olympiakos after Andrea Pirlo had celebrated his 100th Champions League appearance by scoring from a characteristically effortless free kick on Tuesday.
Rattled by embarrassing domestic defeats, Chelsea looked jittery before Olivier Giroud settled their nerves with a close range tap-in shortly after halftime at StamfordBridge following good work by N'Golo Kante and Willian in the build-up.
Images from soccer matches held across Europe on Saturday, March 16.
Images from UEFA Champions League matches played on Wednesday.
Manchester United's troubled season hit a new low on Saturday as Jose Mourinho saw his gamble on introducing a new tactical system backfire with an insipid 3-1 defeat to West Ham United in the Premier League.
IMAGES from the Premier League match played between Liverpool and Luton at Anfield on Wednesday
Thirteen teams have now qualified for the last 32 including Bayer Leverkusen, FC Zurich and Lazio who had already secured places in the next stage of the competition.
Arsenal will have to produce the biggest second leg comeback in a Champions League knockout tie to avoid a seventh successive exit at the last 16 stage when they host Bayern Munich on Tuesday.
Images from the English Premier League matches played on Saturday.
Sanchez, 28, is currently in the final year of his contract. He has been linked with a move to Paris St Germain in the current transfer window.
Arsenal qualified for a 17th successive season with a nervy 1-0 win at home to Besiktas and Malmo made it for the first time with a 3-0 win over Salzburg, whose participation ended in the qualifiers for the ninth time in a row.
Liverpool made it three wins out of three as Mohamed Salah scored twice in a convincing 3-1 victory over Arsenal on Saturday to take control at the top of the Premier League.
Ten-man Premier League leaders Leicester City lost at title-chasing Arsenal, while La Liga pacesetters Barcelona crushed Celta Vigo and Juventus took over from Napoli at the top of Serie A by edging their rivals.
IMAGES from the Premier League matches played on Saturday.
Fellow Serie A sides Atalanta and Lazio also won while Portugal's Vitoria Guimaraes began their match against Salzburg with not a single European player in the team.
Arsenal led a list of nine clubs who grabbed a second win in as many games in the Europa League group phase as France striker Olivier Giroud scored his 100th goal for the club in a 4-2 win at BATE Borisov on Thursday.
Fourth-tier Newport County stunned former FA Cup winners Leeds United with a last-gasp 2-1 win in the third round to spark a joyous pitch invasion at their Rodney Parade ground on Sunday.
A summary of Sunday's action in the Premier League.
IMAGES from the English Premier League matches played on Saturday.
Images from the Champions League round of 16 second leg matches played on Tuesday
Last year's finalists Juventus will face-off against Bundesliga champs Bayern.
Harry Kane's 101st Premier League goal was the difference as Tottenham Hotspur earned a 1-0 win over Arsenal, to continue their fine recent form in north London derbies in front of a Premier League record crowd at Wembley on Saturday.
A 3-0 reality check at the hands of Manchester City was always a moment waiting to happen for Southampton. Just how they bounce back from Sunday's defeat may now determine their fortunes this season.
Man Utd sign Mount from Chelsea on five-year deal
Arsenal climbed into the top four with a laboured 2-1 win over Leicester City.
IMAGES from the Europa League matches played on Thursday
Holders Manchester City will take on RB Leipzig, Red Star Belgrade and Young Boys in Group G.
Photos from the English Premier League matches played on Saturday
